Detalles de la búsqueda
1.
A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling.
Cell;
165(3): 643-55, 2016 Apr 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-27104980
2.
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Mol Cell;
79(1): 180-190.e4, 2020 07 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32619468
3.
Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2).
Bioorg Med Chem;
24(4): 521-44, 2016 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26762835
4.
Hydrothiolation of benzyl mercaptan to arylacetylene: application to the synthesis of (E) and (Z)-isomers of ON 01910·Na (Rigosertib®), a phase III clinical stage anti-cancer agent.
Org Biomol Chem;
11(12): 1964-77, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23386308
5.
ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent.
Cancer Cell;
7(3): 275-86, 2005 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-15766665
6.
Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease.
Nat Commun;
12(1): 4671, 2021 08 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34344863
7.
Design, synthesis and evaluation of (E)-alpha-benzylthio chalcones as novel inhibitors of BCR-ABL kinase.
Bioorg Med Chem;
18(6): 2317-2326, 2010 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20188579
8.
Rigosertib ameliorates the effects of oncogenic KRAS signaling in a murine model of myeloproliferative neoplasia.
Oncotarget;
10(20): 1932-1942, 2019 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-30956775
9.
Design, synthesis, and biological evaluation of (E)-styrylbenzylsulfones as novel anticancer agents.
J Med Chem;
51(1): 86-100, 2008 Jan 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18088089
10.
Targeting protein kinase CK2 and CDK4/6 pathways with a multi-kinase inhibitor ON108110 suppresses pro-survival signaling and growth in mantle cell lymphoma and T-acute lymphoblastic leukemia.
Oncotarget;
9(102): 37753-37765, 2018 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-30701029
11.
Germ line transmission of the Cdk4(R24C) mutation facilitates tumorigenesis and escape from cellular senescence.
Mol Cell Biol;
22(2): 644-56, 2002 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-11756559
12.
Differences in binding of (99m)Tc-disintegrins to integrin alphavbeta3 on tumor and vascular cells.
Nucl Med Biol;
34(4): 371-81, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17499726
13.
Identification and characterisation of a novel heat shock protein 90 inhibitor ONO4140.
Eur J Cancer;
50(11): 1982-92, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24835034
14.
Discovery of 8-cyclopentyl-2-[4-(4-methyl-piperazin-1-yl)-phenylamino]-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonitrile (7x) as a potent inhibitor of cyclin-dependent kinase 4 (CDK4) and AMPK-related kinase 5 (ARK5).
J Med Chem;
57(3): 578-99, 2014 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-24417566
15.
ON01210.Na (Ex-RAD®) mitigates radiation damage through activation of the AKT pathway.
PLoS One;
8(3): e58355, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23505494
16.
Determination of the glucuronide metabolite of ON 013100, a benzylstyrylsulfone antineoplastic drug, in colon cancer cells using LC/MS/MS.
J Pharm Biomed Anal;
75: 138-44, 2013 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-23261806
17.
Design, synthesis, and biological evaluation of (E)-N-aryl-2-arylethenesulfonamide analogues as potent and orally bioavailable microtubule-targeted anticancer agents.
J Med Chem;
56(13): 5562-86, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23750455
18.
(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.
J Med Chem;
55(11): 5174-87, 2012 Jun 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-22587519
19.
Discovery of a clinical stage multi-kinase inhibitor sodium (E)-2-{2-methoxy-5-[(2',4',6'-trimethoxystyrylsulfonyl)methyl]phenylamino}acetate (ON 01910.Na): synthesis, structure-activity relationship, and biological activity.
J Med Chem;
54(18): 6254-76, 2011 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-21812421
20.
A Non-ATP-Competitive Dual Inhibitor of JAK2 and BCR-ABL Kinases: Elucidation of a Novel Therapeutic Spectrum Based on Substrate Competitive Inhibition.
Genes Cancer;
1(4): 331-45, 2010 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-20717479